Nucleosome sliding by Chd1 does not require rigid coupling between DNA‐binding and ATPase domains
نویسندگان
چکیده
منابع مشابه
Nucleosome sliding by Chd1 does not require rigid coupling between DNA-binding and ATPase domains.
Chromatin remodellers are ATP-dependent motor proteins that physically reposition and reorganize nucleosomes. Chd1 and Iswi-type remodellers possess a DNA-binding domain (DBD) needed for efficient nucleosome mobilization; however, it has not been clear how this domain physically contributes to remodelling. Here we show that the Chd1 DBD promotes nucleosome sliding simply by tethering the remode...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2013
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2013.158